Emergency crews are arriving on the scene.
Photos from the scene show a damaged New Jersey Transit rail car inside the station, surrounded by debris.
CBS News executive editor Steve Capus described the scene at the station to CBSN as “devastating.” He saw one person on the ground who appeared to have a broken leg and many others walking around the station looking dazed.
Scores of people were in a triage area at the station, many with bloodied shirts and clothing, Capus reports.
Hoboken is directly across the Hudson River from New York City.